DRUGS AND BREASTFEEDING" DRUGS AND LACTATION "

-


Drug Transfer into Breast Milk 
 Medications generally enter breast milk via passive diffusion
 Transcellular 
            transverse capillary wall; small non-ionized lipid soluble molecules 
             ionized molecules and small proteins enter basal part of cell from interstitial water 
Intercellular
       avoids alveolar cell entirely - large molecules Ig, cow milk protein. 
 Ionophore 
Active transport

 Factors affecting transfer of drugs into breast milk
  maternal serum drug concentration*
  molecular weight
 degree of protein binding* 
 relative drug lipophilicity
 pKa 
 half-life
 active transport Drug Transfer

Cautions and Contraindicated Drugs 
Caution
 beta-blockers – reports of hypotension, bradycardia
  lithium – significant infant serum concentrations (variable)
 amiodarone
 lamotrigine – decreased metabolism, sig. plasma levels 
 Contraindicated
 Antineoplastics 
 Radioactive isotopes
 Ergotamine

Comments

Post a Comment

Popular posts from this blog

15 Keys you Must Remember to be Successful

-
Image
If you want to be successful you must be one of the pioneers to achieve their goals do not achieve success happens coincidence coincidence that good comes as a gift for your effort and fatigue so you must put this in your eyes to keep your path on your way to success 1. Remember your achievements: On the days when you are in despair and wish you never started this road and feel that all your decisions have been wrong just remember what you have achieved in the previous period. Remember your goals that you may have reached or approached, this can bring back your spirit and activity and help you defeat despair within yourself 2. Remember to plan ahead: Success is not easily achieved You will always find obstacles in your way so it is important to develop a future plan to overcome the obstacles you can face in the future 3. Remember to do what pleases your passion: When you work to satisfy your passion, you will love this work, which gives you a sense of hap...
Read more

FIRST WORLD WAR : CAUSES RESULTS and HISTORY

-
World War I is also called the Great War and the war that ended all wars is a war that took place in Europe and then spread to the rest of the world during the years between 1914 and 1918. The war began when the Austro-Hungarian Empire invaded the Kingdom of Serbia. Russia declared war on Austria. Germany entered the war as an ally of Austria and France and Britain entered as allies of Russia. The tripartite accord was composed of Russia, France and the United Kingdom, and the tripartite alliance was the Austro-Hungarian Empire, Germany and Italy. Chemical weapons were first used in World War I and civilians were first bombed from the sky in history. The war witnessed human victims not seen in history before, and the ruling and dominant dynasties of Europe, which originated in the Crusades, fell and the political map of Europe was changed. World War I is the seed of ideological movements such as communism and future conflicts such as World War II, and even the Cold War. The w...
Read more

Jesus Christ is peace

-
The history of the world is full of wars and battles that have claimed the lives of thousands and even millions of people throughout the ages Why all these wars? Disputes over power and control over land and states If all the world would outweigh the danger of wars that have destroyed mankind for many generations I hope that peace will prevail all over the world and that all conflicts and wars will disappear and all the world will remain one man Love is spread among all peoples of the world This is the commandment of Christ to all the world that peace prevails and wars disappear Jesus said, "This is my commandment to love one another." Is the commandment of Jesus Christ for the whole world by love for all people and the distance from hatred and adversity
Read more