DRUGS AND BREASTFEEDING" DRUGS AND LACTATION "
Drug Transfer into Breast Milk Medications generally enter breast milk via passive diffusion Transcellular transverse capillary wall; small non-ionized lipid soluble molecules ionized molecules and small proteins enter basal part of cell from interstitial water Intercellular avoids alveolar cell entirely - large molecules Ig, cow milk protein. Ionophore Active transport Factors affecting transfer of drugs into breast milk maternal serum drug concentration* molecular weight degree of protein binding* relative drug lipophilicity pKa half-life active transport Drug Transfer Cautions and Contraindicated Drugs Caution beta-blockers – reports of hypotension, bradycardia lithium – significant infant serum concentrations (va...