DRUGS AND BREASTFEEDING" DRUGS AND LACTATION "
 
     Drug Transfer into Breast Milk    Medications generally enter breast milk via passive diffusion   Transcellular                transverse capillary wall; small non-ionized lipid soluble molecules                ionized molecules and small proteins enter basal part of cell from interstitial water    Intercellular         avoids alveolar cell entirely - large molecules Ig, cow milk protein.    Ionophore   Active transport   Factors affecting transfer of drugs into breast milk    maternal serum drug concentration*    molecular weight   degree of protein binding*    relative drug lipophilicity   pKa    half-life   active transport Drug Transfer   Cautions and Contraindicated Drugs   Caution   beta-blockers – reports of hypotension, bradycardia    lithium – significant infant serum concentrations (va...
 
 
 
 
 
 
 
